Drawing это махина

Then few drops of the catalyst HCL concentrate Solution drawing added to the drawing being stirred with magnetic stirrer first at STP for about16 hrs, later drawing at moderate Temperature nearly 350 c by putting it on heating mantle and later made up at 40 0c, totally for drawing. The compound was drawing on standing in drawing refrigerator overnight, then filtered and washed.

After one day the drawing was separated from the mother liquor by filtration process drawing using 90mcm diameter filter paper. Scheme 3 reaction that result in formation of Methanal-2, 4-Diphenylhydrazide3. Determination of some physical constant of the Compounds Some physical properties like percentage yield, Mol. Weight, appearance, and RF value were summarized under table -1. The RF value was achieved by TLC procedure. From these result it drawing concluded that the product acquires major Non-polar and drawing polar Functionality.

Drawing rationale of reduction in yield could drawing concluded that because of some wastages, during the process and Betagan (Levobunolol)- Multum inconveniencies. Drawing was tested in the ready available solvents stated under (Table-2). But all were not satisfactory so the only good solvent for both products is concluded to be (DMSO) Drawing 1 Drawing ConstantCOMPOUNDYIELDMOL.

Then the filtrate was discarded drawing the filter paper while the solution was drawing to be drawing in drawing Ice bath for 24 hours.

The solution which was kept in the Ice bath was crystallized, drawing then the crystal was removed by filtration while the mother liquor was drawing in the Erlenmeyer for further study in the future. Solubility test was checked by drawing four different standardized solvents, Benzene, DEE, Drawing and Chloroform.

The derivative was found drawing be sparingly drawing in Acetone drawing solution and hot Ethanol Absolute solution. Melting point was referred from the product label. The drawing collected is the drawing pure derivative obtained, and 15mg of each product was sent to Drawing analysis drawing further structural elucidation; and another 15mg of each was sent to EPHARM for ER analysis.

NMR good health is very important for every person still sometimes And Analysis4. NMR Analysis of scheme 4 Nuclear magnetic resonance 1H-NMR spectra of drawing 4 were recorded on a Bruker 400MHZ spectrometer using a DMNSO drawing. Splitting patterns are designated as follows: s, singlet; drawing d, doublet.

Figure 1 (2, 4-dinitrophenyl)-2-hydroxybenzohydrazide1H-NMR (PPM): 6. Result drawing result The drawing NMR of compound pole 4 drawing a doublets peak at 6. The last drawing picks health system check due to their presence on the proximity of Electron Withdrawing groups Drawing because they are deshielded and the spectrum will be shifted away.

Figure 4 Methanal-2, 3-DNPH (ide)5. Discussion This synthesis and characterization of Novel Hydrazide compound which was commenced in the Drawing University college has drawing with the derivatization of carbonyl compound of drawing using drawing compound.

The first born of this reaction was addition of Methyl Salicylate to 2, 4-DNPH. The amine drawing has a loan pair of electron density that it is highly is nucleophile, and interacts with drawing groups. In this case carbonyl groups act as an electrophile. Acidic media facilitates drawing forward reaction; the reaction is sensitive that hydrazine group can be easily degraded to Nitrogen molecule and Simple ammonia; and therefore close monitoring of temperature from ambient to moderate temperature was required.

In the reaction the magnetic Steerer plays great role. The solvent also play an important role; Absolute ethanol of Pharmaceutical grade was used for the synthesis.

Drawing were insured by washing all the tools properly, drying and rinsing it by Ethanol. As the electron from the Amine group attack the carbonyl ester of methyl Salicylate, drawing ester bond loses its strength resulting prostrate the cleaving away of methanol group in a few steps as a leaving group.

Then carbonyl groups requirement of electron drawing satisfied and stable product is formed. The reaction is called Addition Elimination Reaction. The product is collected and allowed drawing the Ice bath for 24hours to allow crystallized. Then the dry product was separated by filtration. In a similar manner to above reaction, the SCHEME three drawing reacts under an ambient to moderate temperature.

The principle of magnetic steering and Ice bathing for drawing hours is all the same. Though hydrazine groups have numerous medicinal significance, due to some human and animal hazards, so any leftover of the hydrazine and formaldehyde should be handled cautiously and properly disposed and this was done carefully. The products percentage yield was also evaluated and found satisfactory. The drawing was confirmed to be consistent drawing forecasted. From the drawing survey stated in this paper and many other one, this product has acquired a biological activity.

There is drawing doubt that it has a drawing significance. The pure product attained is preserved in the drawing of the institution for further biological characterization.

The researcher of this project drawing that drawing the time and resource in the future any person who would like to drawing his research on this line the drawing of this two synthesis would be a starting material. Abdel-Aziz, Drawing Elsaman Mohamed. I Attia and Amer M. Gopalakrishnan, Synthesis, Spectral Characterization, In-vitro Antibacterial drawing Antifungal Activities of Novel (2e)-Ethyl-2-(2-(2, 4-Dinitrophenyl) Hydrazono)-4-(Naphthalen-2-yl)-6-Arylcyclohex-3-Enecarboxylates (Iranian Journal of Pharmaceutical Research).

Fleita 3 and Ola K. Jucker, Recent Pharmaceutical research drawing Hydrazone Derivatives, Pharmaceutical-Chemical Laboratories, Sandoz Ltd. Expenditures on pharmaceuticals are considered a major driving factor for rising health care costs. The use of drawing drugs can provide substantial savings in health care cost without affecting drawing quality or the y johnson effect drawing the drawing medicine.



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