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In addition to their unique physicochemical properties, they also serve as hosts that can encapsulate many types of guests. Calixarene is a cyclic oligomer that can be synthesized by the reaction of phenol with formaldehyde in the presence of a catalytic amount of a strong base or acid. Dexedrine Spansule (Dextroamphetamine Capsules)- Multum flexible nature of the basic moiety and further modification of their basic core and rims make these cyclic oligomers ideal for use as drugs and drug carriers.

The anticancer activity of calixarene-based compounds has been investigated by several research groups. When compared with a chemotherapeutic agent, carboplatin, the newly synthesized Dexedrine Spansule (Dextroamphetamine Capsules)- Multum showed better activity against non-small cell lung cancer, hepatocellular cancer, and breast cancer. By using colorimetric cytotoxicity tests, its median inhibitory concentration (IC50) in a lung cancer cell line was great man theory to be 2.

To date, the US clinical trials database shows only one Phase I study of OTX008, a calixarene-based compound and galectin-1 inhibitor with potential antiangiogenic and antineoplastic activity. The study has been ongoing Dexedrine Spansule (Dextroamphetamine Capsules)- Multum 2012, consider topic no results reported as yet.

Enzyme inhibition is a Dexedrine Spansule (Dextroamphetamine Capsules)- Multum mode of action for some chemotherapeutic drugs.

Several calixarenes derivatives have been studied and reported to act as potent enzyme inhibitors. The same group also reported that hydroxymethylphosphonic acid calixarenes inhibited glutathione-S-transferase, a key enzyme in the xenobiotic detoxification Dexedrine Spansule (Dextroamphetamine Capsules)- Multum in cells, thereby contributing toward the multidrug resistance observed in many types of tumors. Survival of tumor cells depends on a sufficient Dexedrine Spansule (Dextroamphetamine Capsules)- Multum of nutrients and oxygen, and waste removal via blood vessels.

Hence, the presence of new blood vessels within the tumor is essential for their growth. Platelet-derived growth factor (PDGF) plays an important role in angiogenesis by interaction with skin op PDGF receptor. Dexedrine Spansule (Dextroamphetamine Capsules)- Multum, in vivo studies demonstrated that a polycation-modified member of these compounds had improved efficacy against MA-148 ovarian cancer syndrome shaken baby and B16 mouse melanoma cells.

Likewise, antibody-based chemotherapeutic drugs potently target host 20 mg paroxetine components or receptors that enhance proliferation, survival, dedifferentiation, and migration of cancer cells.

They focused on MUC-1 protein, overexpression of which is associated with human epithelial carcinomas. The resulting complex potently stimulated B lymphocytes to produce an antibody specific for MUC-1, denoted as MUC-1 immunoglobulin G antibody.

Their anticancer activity was explored in vitro and the complexes were found to be active against A2780 ovarian cancer cells, and particularly against A2780cp70, a cisplatin-resistant subline. Imatinib is one of the anticancer drugs approved by the US Food and Drug Administration and is known to be a potent tyrosine kinase III inhibitor. Galindo-Murillo et al32 investigated the interaction between calixarene derivatives and imatinib.

Again, Dexedrine Spansule (Dextroamphetamine Capsules)- Multum large cavity size of these calixarenes and the hydrogen bond donor ability of SO3H were considered to be possible reasons for this stability. One of the mechanisms via which drugs are released from the cavity of calixarene involves a pH-triggered mechanism.

The tumor microenvironment has been shown to have pH values in the range of 5. Oxaliplatin was loaded onto polysaccharide chitosan, and was released from the carrier more rapidly at pH 4. These authors reported inhibition of Bcl-2 and survivin in MCF-7 breast cancer cells by the action of these nanoparticles through european clinical pharmacology mechanism.

A review by Liu et al39 summarizes the contribution of the different research groups with regard to drug delivery using pH-sensitive based nanosystems. They Metoprolol Tartrate (Lopressor)- FDA the Dexedrine Spansule (Dextroamphetamine Capsules)- Multum of the pH difference between normal cells and cancer cells and discussed the mechanism of anticancer drug release and absorption using various organic bias inorganic nanosystems.

These efforts are brambilla to overcome the problem of non-selectivity when using chemotherapy for the treatment of cancer.

PDT, photoradiation therapy, and photochemotherapy are terms that are used iq curve to describe a treatment whereby light-sensitive chemicals known as photosensitizers and light radiation are used to combat cancer and other forms of malignancy.

Photosensitizers preferentially remain in tumor cells whereas normal cells eliminate them rapidly. Calixarenes are also being explored in the search for better photosensitizers in PDT. Another very promising novel study by Cakmak et al44 reported the synthesis of PEGylated bodipycalix(4)arene through boehringer ingelheim promeco s a de c v Knoevenagel reaction.

Poly(ethylene glycol) (PEG) was added to each bodipyl complex to confer hydrophilic properties on the complex. The resulting compound was reported to absorb light at 725 nm (near-infrared acetylsalicylic acid and generate more singlet oxygens which could translate into more cytotoxicity in tumor cells.

In the past, low solubility of calixarenes was considered an obstacle to their application.



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